BDBM21184 N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(4-methyl-1,3-oxazol-5-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide::Pyrimidine analogue, 36

SMILES CN1CCN(CC(=O)Nc2cc(nc(n2)-n2nc(C)cc2C)-c2ocnc2C)CC1

InChI Key InChIKey=LEQUNUQCDRRCMW-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 21184   

TargetAdenosine receptor A2a(Human)
Neuroscience

LigandPNGBDBM21184(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(4-methyl-1,...)
Affinity DataKi:  190nM ΔG°:  -9.07kcal/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2008
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Neuroscience

LigandPNGBDBM21184(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(4-methyl-1,...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.75kcal/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2008
Entry Details Article
PubMed