BDBM21164 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]-1H-imidazole::Imidazole-based ligand, 15

SMILES COc1ccc(CCCOC(Cn2ccnc2)c2ccc(OC)cc2)cc1

InChI Key InChIKey=HLMBXBGDBBCYII-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 21164   

TargetCytochrome P450 3A4(Human)
Astrazeneca

LigandPNGBDBM21164(1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propo...)
Affinity DataIC50: 45nMpH: 7.4 T: 2°CAssay Description:The inhibition of recombinant human CYP3A4 was measured as the ability to perform a debenzylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Bef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Astrazeneca

LigandPNGBDBM21164(1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propo...)
Affinity DataIC50: 220nMAssay Description:The inhibition of recombinant human CYP3A4 was measured as the ability to perform a debenzylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Bef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
TargetShort transient receptor potential channel 6(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM21164(1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propo...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of mouse TRPC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Instituto De Qu£Mica M£Dica

Curated by ChEMBL
LigandPNGBDBM21164(1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propo...)
Affinity DataIC50: 800nMAssay Description:Antagonist activity at TRPM8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed