BDBM210850 US9290467, 20

SMILES FC(F)(F)c1ccc2c(OC\C=C\COc3ccc(C[C@H](NC2=O)C(=O)NC2(CC2)C#N)cc3Cl)c1

InChI Key InChIKey=FAIWYBGWPKDNIJ-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 210850   

TargetProcathepsin L(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM210850(US9290467, 20)
Affinity DataIC50: 47.7nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
Go to US Patent

TargetProcathepsin L(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM210850(US9290467, 20)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human CatL using Cbz-Phe-Arg-AMC as substrate measured over 30 mins by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2020
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM210850(US9290467, 20)
Affinity DataKi:  20nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2020
Entry Details Article
PubMed