BDBM210754 US9290454, 3.6::US9290454, 3.7

SMILES COc1ccccc1-n1c(CCCCC(O)=O)cc2cc(ccc2c1=O)C(=O)N[C@H](C)c1ccc(F)cc1

InChI Key InChIKey=JUMSOIBYWBSHJA-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 210754   

TargetProstaglandin D2 receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM210754(US9290454, 3.7 | US9290454, 3.6)
Affinity DataKi:  18.7nM ΔG°:  -11.4kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding was performed using filtration or scintillation proximity assay (SPA) technology. SPA assays were done at room temperature in 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
Go to US Patent

TargetProstaglandin D2 receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM210754(US9290454, 3.7 | US9290454, 3.6)
Affinity DataKi:  19nMAssay Description:Antagonist activity at human CRTh2 expressed in HEK cells assessed as inhibition of DK-PGD2-mediated attenuation of forskolin-induced cAMP accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM210754(US9290454, 3.7 | US9290454, 3.6)
Affinity DataKi:  363nM ΔG°:  -9.52kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding was performed using filtration or scintillation proximity assay (SPA) technology. SPA assays were done at room temperature in 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
Go to US Patent