BDBM210753 US9290454, 3.5

SMILES COc1cccc(c1)-n1c(CCCCC(O)=O)cc2cc(ccc2c1=O)C(=O)N[C@H](C)c1ccc(F)cc1

InChI Key InChIKey=DOKVJJBSEMHNGP-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 210753   

TargetProstaglandin D2 receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM210753(US9290454, 3.5)
Affinity DataKi:  13nMAssay Description:Antagonist activity at human CRTh2 expressed in HEK cells assessed as inhibition of DK-PGD2-mediated attenuation of forskolin-induced cAMP accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM210753(US9290454, 3.5)
Affinity DataKi:  13.1nM ΔG°:  -11.6kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding was performed using filtration or scintillation proximity assay (SPA) technology. SPA assays were done at room temperature in 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
Go to US Patent