BDBM21038 (2R,3S,6Z,14S,15S,17R)-6-({[3-(dimethylamino)propyl](methyl)amino}methylidene)-8,14,17-trihydroxy-3-(methoxymethyl)-2,15-dimethyl-4-oxatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1(10),7-diene-5,9-dione::17-Hydroxywortmannin Analogue, 15

SMILES COC[C@H]1OC(=O)C(=CN(C)CCCN(C)C)C2C(=O)C(=O)C3=C([C@H](O)C[C@]4(C)[C@@H](O)CCC34)[C@@]12C

InChI Key InChIKey=BSVBYHLBZUBRKC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 21038   

LigandPNGBDBM21038((2R,3S,6Z,14S,15S,17R)-6-({[3-(dimethylamino)propy...)
Affinity DataIC50: 638nMpH: 7.5 T: 2°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM21038((2R,3S,6Z,14S,15S,17R)-6-({[3-(dimethylamino)propy...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2008
Entry Details Article
PubMed