BDBM210300 US9546153, ex. 367

SMILES CC(C)Nc1cc(ncc1C(=O)NC[C@H](C(C)(C)O)F)Nc2c(cn3c(n2)ccn3)F

InChI Key InChIKey=SNCZIVUNTWOQAF-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 210300   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50: 4.80nMpH: 7.2 T: 2°CAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2018
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of IRAK4 (unknown origin) using FL-IPTSPITTTYFFFKKK peptide and ATP as substrate incubated for 60 mins by fluorescence based caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50: 370nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50: 920nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTRAF2 and NCK-interacting protein kinase(Human)
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50: 130nMAssay Description:Inhibition of human wild type partial length TNIK (D4-K311 residues) expressed in bacterial expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human cKit (544 to end residues) expressed in baculovirus infected Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of N-terminal His6-tagged human full length recombinant LCK expressed in baculovirus infected Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50: 980nMAssay Description:Inhibition of human wild type partial length TYRO3 (497 to 814 residues) expressed in bacterial expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 3(Human)
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50: 760nMAssay Description:Inhibition of human wild type partial length IRAK3 (147 to 596 residues) expressed in bacterial expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed