BDBM210057 US10576087, Compound 2.35::US9273046, 2.35::US9895376, Compound 2.35

SMILES Cc1cc(Oc2ccnc3NC(=O)CCc23)cc2C3C(Oc12)C3c1nc2ccc(cc2[nH]1)C(F)(F)F

InChI Key InChIKey=LWHCGCXCKRIJCQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 210057   

TargetSerine/threonine-protein kinase B-raf(Human)
Beigene

US Patent
LigandPNGBDBM210057(US9273046, 2.35 | US9895376, Compound 2.35 | US105...)
Affinity DataIC50: 61nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
Go to US Patent

LigandPNGBDBM210057(US9273046, 2.35 | US9895376, Compound 2.35 | US105...)
Affinity DataIC50: 12nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Beigene

US Patent
LigandPNGBDBM210057(US9273046, 2.35 | US9895376, Compound 2.35 | US105...)
Affinity DataIC50: 61nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM210057(US9273046, 2.35 | US9895376, Compound 2.35 | US105...)
Affinity DataIC50: 12nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Beigene

US Patent
LigandPNGBDBM210057(US9273046, 2.35 | US9895376, Compound 2.35 | US105...)
Affinity DataIC50: 61nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

LigandPNGBDBM210057(US9273046, 2.35 | US9895376, Compound 2.35 | US105...)
Affinity DataIC50: 12nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent