BDBM210034 US10576087, Compound 1.1::US9273046, 1.1::US9895376, Compound 1.1

SMILES O=C1CCc2c(Oc3ccc4CC5C(C5c4c3)c3nc4ccccc4[nH]3)ccnc2N1

InChI Key InChIKey=UDDWKWDIETXXHS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 210034   

TargetSerine/threonine-protein kinase B-raf(Human)
Beigene

US Patent
LigandPNGBDBM210034(US9273046, 1.1 | US9895376, Compound 1.1 | US10576...)
Affinity DataIC50: 11nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
Go to US Patent

LigandPNGBDBM210034(US9273046, 1.1 | US9895376, Compound 1.1 | US10576...)
Affinity DataIC50: 1.40nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Beigene

US Patent
LigandPNGBDBM210034(US9273046, 1.1 | US9895376, Compound 1.1 | US10576...)
Affinity DataIC50: 11nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM210034(US9273046, 1.1 | US9895376, Compound 1.1 | US10576...)
Affinity DataIC50: 1.40nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Beigene

US Patent
LigandPNGBDBM210034(US9273046, 1.1 | US9895376, Compound 1.1 | US10576...)
Affinity DataIC50: 11nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

LigandPNGBDBM210034(US9273046, 1.1 | US9895376, Compound 1.1 | US10576...)
Affinity DataIC50: 1.40nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent