BDBM210028 US10576087, Compound 3.1::US9273046, 3.1

SMILES CNC(=O)c1cc(Oc2ccc3OC4C(C4c3c2)c2nc3ccc(cc3[nH]2)C(F)(F)F)ccn1

InChI Key InChIKey=JKQCEJLFHYXPNJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 210028   

TargetSerine/threonine-protein kinase B-raf(Human)
Beigene

US Patent
LigandPNGBDBM210028(US9273046, 3.1 | US10576087, Compound 3.1)
Affinity DataIC50: 56nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
Go to US Patent

LigandPNGBDBM210028(US9273046, 3.1 | US10576087, Compound 3.1)
Affinity DataIC50: 6.5nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Beigene

US Patent
LigandPNGBDBM210028(US9273046, 3.1 | US10576087, Compound 3.1)
Affinity DataIC50: 56nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

LigandPNGBDBM210028(US9273046, 3.1 | US10576087, Compound 3.1)
Affinity DataIC50: 6.5nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent