BDBM209912 US9273014, Comparative Compound 48::US9427442, Comparative Compound 29

SMILES CCCN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CC(C)C)[C@H](CC=C)C(N)=O)C1=O)c1ccccc1

InChI Key InChIKey=NBOUPMNHRXSDBV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 209912   

LigandPNGBDBM209912(US9273014, Comparative Compound 48 | US9427442, Co...)
Affinity DataIC50: 12.3nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
Go to US Patent

LigandPNGBDBM209912(US9273014, Comparative Compound 48 | US9427442, Co...)
Affinity DataIC50: 12.5nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
Go to US Patent

LigandPNGBDBM209912(US9273014, Comparative Compound 48 | US9427442, Co...)
Affinity DataIC50: 12.3nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent

LigandPNGBDBM209912(US9273014, Comparative Compound 48 | US9427442, Co...)
Affinity DataIC50: 12.5nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent