BDBM209911 US9273014, Comparative Compound 47::US9427442, Comparative Compound 28

SMILES CCCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccc(Cl)cc2)c2ccccc2N(C)C1=O)C(N)=O

InChI Key InChIKey=JADHURSZAFCXCI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 209911   

LigandPNGBDBM209911(US9273014, Comparative Compound 47 | US9427442, Co...)
Affinity DataIC50: 5.10nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
Go to US Patent

LigandPNGBDBM209911(US9273014, Comparative Compound 47 | US9427442, Co...)
Affinity DataIC50: 13.5nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
Go to US Patent

LigandPNGBDBM209911(US9273014, Comparative Compound 47 | US9427442, Co...)
Affinity DataIC50: 5.10nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent

LigandPNGBDBM209911(US9273014, Comparative Compound 47 | US9427442, Co...)
Affinity DataIC50: 13.5nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent