BDBM209498 US10328074, Example III-39::US11077107, Example III-39::US9266891, III-39

SMILES COc1cc2n(Cc3ccccn3)c(nc2cn1)-c1cn2c(C)nnc2c(NC(C)C)n1

InChI Key InChIKey=UQEASOOHOYLOSE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 209498   

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209498(US9266891, III-39 | US10328074, Example III-39 | U...)
Affinity DataIC50: 126nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209498(US9266891, III-39 | US10328074, Example III-39 | U...)
Affinity DataIC50: 126nMAssay Description:This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
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TargetBromodomain-containing protein 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM209498(US9266891, III-39 | US10328074, Example III-39 | U...)
Affinity DataIC50: 126nMAssay Description:Displacement of biotinylated tetra-acetylated histone H4 peptide from GST-tagged BRD4-BD1 (44 to 168 residues) (unknown origin) measured after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM209498(US9266891, III-39 | US10328074, Example III-39 | U...)
Affinity DataIC50: 126nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent