BDBM209414 US9266890, I-24

SMILES CN1c2cnc(nc2N([C@@H]3CCC[C@@H]3C1=O)C4CCCC4)Nc5ccc(cc5)C(=O)N

InChI Key InChIKey=VJDBYVPTQWPRPA-UHFFFAOYSA-N

Data  1 KI  1 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 209414   

TargetSerine/threonine-protein kinase PLK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM209414(US9266890, I-24)
Affinity DataKd:  18nMAssay Description:In vitro Plk1 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 7(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM209414(US9266890, I-24)
Affinity DataKd:  320nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Uit The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM209414(US9266890, I-24)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Uit The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM209414(US9266890, I-24)
Affinity DataKi:  2.02E+3nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)