BDBM20913 Isoxazole, 40d::N-ethyl-5-(5-ethyl-2,4-dihydroxyphenyl)-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide::US10413550, Example 55::US11234987, Example 55::US9718793, 55

SMILES CCNC(=O)c1noc(c1-c1ccc(CN2CCOCC2)cc1)-c1cc(CC)c(O)cc1O

InChI Key InChIKey=RNLVKRYMKWCANV-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 20913   

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM20913(N-ethyl-5-(5-ethyl-2,4-dihydroxyphenyl)-4-[4-(morp...)
Affinity DataIC50: 29nM EC50:  25nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
The Institute of Cancer Research

US Patent
LigandPNGBDBM20913(N-ethyl-5-(5-ethyl-2,4-dihydroxyphenyl)-4-[4-(morp...)
Affinity DataIC50: 1.00E+4nMAssay Description:Fluorescence polarization {also known as fluorescence anisotropy} measures the rotation of a fluorescing species in solution, where the larger molecu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
Go to US Patent

LigandPNGBDBM20913(N-ethyl-5-(5-ethyl-2,4-dihydroxyphenyl)-4-[4-(morp...)
Affinity DataIC50: 1.00E+4nMAssay Description: (1) Greiner 384-well (Greiner 781101) or Costar 384-well flat-bottomed polystyrene multiwell plates (VWR). (2) Assay buffer of (a) 100 mM Tris-HCl, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetATP-dependent molecular chaperone HSP82(Baker's yeast)
Cancer Research Technology

US Patent
LigandPNGBDBM20913(N-ethyl-5-(5-ethyl-2,4-dihydroxyphenyl)-4-[4-(morp...)
Affinity DataIC50: 1.00E+4nMAssay Description:1) Costar 96-well black assay plate. Assay buffer of (a) 100 mM Tris pH7.4; (b) 20 mM KCl; (c) 6 mM MgCl2. Stored at room temperature.3) BSA (bovine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent