BDBM209075 US9266877, 21

SMILES OC(=O)c1nc(ccc1-c1cnn(Cc2ccccc2)c1)N1CCc2cccc(C(=O)Nc3nc4cccc(Cl)c4s3)c2C1

InChI Key InChIKey=RZBQGRFSPSOIJX-UHFFFAOYSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 209075   

TargetBcl-2-like protein 1(Mouse)
Abbvie

US Patent
LigandPNGBDBM209075(US9266877, 21)
Affinity DataEC50: >1.00E+3nMAssay Description:The efficacy of the compounds of Formula (I) can also be determined in cell-based killing assays using a variety of cell lines and mouse tumor models...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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TargetBcl-2-like protein 1(Human)
Abbvie

US Patent
LigandPNGBDBM209075(US9266877, 21)
Affinity DataKi:  183nM ΔG°:  -9.19kcal/moleT: 2°CAssay Description:The measurement of competition of compounds of Formula (I) with F-Bak for a Bcl-2 family protein (Bcl-xL) binding site using a Time Resolved Fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent