BDBM208998 (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol::US9233167, Codeine

SMILES COc1ccc2C[C@@H]3C4C=C[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C

InChI Key

Data  2 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 208998   

TargetMu-type opioid receptor(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM208998(US9233167, Codeine | (4R,4aR,7S,7aR,12bS)-9-methox...)
Affinity DataEC50:  1.04E+4nMT: 2°CAssay Description:Briefly, suspensions of cells expressing either the mu, kappa or delta opioid receptors were prepared in buffer containing 0.5 mM isobutyl-methyl xan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM208998(US9233167, Codeine | (4R,4aR,7S,7aR,12bS)-9-methox...)
Affinity DataKi:  1.95E+3nM ΔG°:  -7.78kcal/moleT: 2°CAssay Description:Briefly, serial dilutions of the test compounds were placed in a 96-well plate to which were added SPA beads, membrane and radioligand. The assay con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM208998(US9233167, Codeine | (4R,4aR,7S,7aR,12bS)-9-methox...)
Affinity DataKi:  2.81E+4nM ΔG°:  -6.21kcal/moleT: 2°CAssay Description:Briefly, serial dilutions of the test compounds were placed in a 96-well plate to which were added SPA beads, membrane and radioligand. The assay con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
Go to US Patent