BDBM208983 US9233167, a-6-mPEG2-O-Morphine

SMILES COCCOCCO[C@H]1CC[C@@]2(O)C3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3C)c45

InChI Key InChIKey=HNFMRKGGZDJFSW-UHFFFAOYSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 208983   

TargetMu-type opioid receptor(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM208983(US9233167, a-6-mPEG2-O-Morphine)
Affinity DataEC50:  93.3nMT: 2°CAssay Description:Briefly, suspensions of cells expressing either the mu, kappa or delta opioid receptors were prepared in buffer containing 0.5 mM isobutyl-methyl xan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM208983(US9233167, a-6-mPEG2-O-Morphine)
Affinity DataEC50:  641nMT: 2°CAssay Description:Briefly, suspensions of cells expressing either the mu, kappa or delta opioid receptors were prepared in buffer containing 0.5 mM isobutyl-methyl xan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM208983(US9233167, a-6-mPEG2-O-Morphine)
Affinity DataKi:  22.0nM ΔG°:  -10.4kcal/moleT: 2°CAssay Description:Briefly, serial dilutions of the test compounds were placed in a 96-well plate to which were added SPA beads, membrane and radioligand. The assay con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM208983(US9233167, a-6-mPEG2-O-Morphine)
Affinity DataKi:  404nM ΔG°:  -8.72kcal/moleT: 2°CAssay Description:Briefly, serial dilutions of the test compounds were placed in a 96-well plate to which were added SPA beads, membrane and radioligand. The assay con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
Go to US Patent

TargetDelta-type opioid receptor(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM208983(US9233167, a-6-mPEG2-O-Morphine)
Affinity DataKi:  2.60E+3nM ΔG°:  -7.61kcal/moleT: 2°CAssay Description:Briefly, serial dilutions of the test compounds were placed in a 96-well plate to which were added SPA beads, membrane and radioligand. The assay con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
Go to US Patent