BDBM208980 US9233167, a-6-mPEG1-O-Codeine

SMILES COCCO[C@H]1C=CC2C3Cc4ccc(OC)c5OC1[C@]2(CCN3C)c45

InChI Key InChIKey=CCFZKAPEUYIPRY-UHFFFAOYSA-N

Data  2 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 208980   

TargetMu-type opioid receptor(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM208980(US9233167, a-6-mPEG1-O-Codeine)
Affinity DataEC50:  8.57E+3nMT: 2°CAssay Description:Briefly, suspensions of cells expressing either the mu, kappa or delta opioid receptors were prepared in buffer containing 0.5 mM isobutyl-methyl xan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
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TargetMu-type opioid receptor(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM208980(US9233167, a-6-mPEG1-O-Codeine)
Affinity DataKi:  1.82E+3nM ΔG°:  -7.82kcal/moleT: 2°CAssay Description:Briefly, serial dilutions of the test compounds were placed in a 96-well plate to which were added SPA beads, membrane and radioligand. The assay con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM208980(US9233167, a-6-mPEG1-O-Codeine)
Affinity DataKi:  5.47E+4nM ΔG°:  -5.81kcal/moleT: 2°CAssay Description:Briefly, serial dilutions of the test compounds were placed in a 96-well plate to which were added SPA beads, membrane and radioligand. The assay con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
Go to US Patent