BDBM208813 US10221197, Compound 37::US9266878, 38a

SMILES C[C@H](Nc1ncnc(N)c1C#Cc1ccccn1)c1nc2cccc(Cl)c2c(=O)n1-c1cccc(c1)C(N)=O

InChI Key InChIKey=PTQYEXPCYCYVAH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 208813   

LigandPNGBDBM208813(US9266878, 38a | US10221197, Compound 37)
Affinity DataIC50: 100nMpH: 7.4 T: 2°CAssay Description:PI3K isoforms were assayed under initial rate conditions in the presence of 25 mM Hepes (pH 7.4), and 2xKm ATP (100-300 uM), 10 uM PIP2, 5% glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
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LigandPNGBDBM208813(US9266878, 38a | US10221197, Compound 37)
Affinity DataIC50: 100nMpH: 7.4 T: 2°CAssay Description:PI3K isoforms were assayed under initial rate conditions in the presence of 25 mM Hepes (pH 7.4), and 2xKm ATP (100-300 uM), 10 uM PIP2, 5% glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
Go to US Patent

LigandPNGBDBM208813(US9266878, 38a | US10221197, Compound 37)
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:PI3K isoforms were assayed under initial rate conditions in the presence of 25 mM Hepes (pH 7.4), and 2xKm ATP (100-300 uM), 10 uM PIP2, 5% glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
Go to US Patent

LigandPNGBDBM208813(US9266878, 38a | US10221197, Compound 37)
Affinity DataIC50: 550nMpH: 7.4 T: 2°CAssay Description:PI3K isoforms were assayed under initial rate conditions in the presence of 25 mM Hepes (pH 7.4), and 2xKm ATP (100-300 uM), 10 uM PIP2, 5% glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
Go to US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Gilead Sciences

US Patent
LigandPNGBDBM208813(US9266878, 38a | US10221197, Compound 37)
Affinity DataIC50: 2.43E+5nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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LigandPNGBDBM208813(US9266878, 38a | US10221197, Compound 37)
Affinity DataIC50: 7.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

LigandPNGBDBM208813(US9266878, 38a | US10221197, Compound 37)
Affinity DataIC50: 1.00E+7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent