BDBM208769 US9266876, 236

SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)nc1C)c1sc(nc1-c1nc2ccc(cc2[nH]1)-c1noc(C)n1)C(F)(F)F

InChI Key InChIKey=SXYUBRILLHMIAQ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 208769   

LigandPNGBDBM208769(US9266876, 236)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
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TargetC-X-C chemokine receptor type 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM208769(US9266876, 236)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at human recombinant CXCR3 expressed in CHO-K1 cells measured after 10 mins in presence of CXCL10 by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM208769(US9266876, 236)
Affinity DataIC50: 239nMAssay Description:Antagonist activity at human recombinant CXCR3 in human venous blood assessed as receptor internalization measured for 30 mins in presence of CXCL10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM208769(US9266876, 236)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsome using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM208769(US9266876, 236)
Affinity DataIC50: 1.60E+4nMAssay Description:Antagonist activity at 5-HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM208769(US9266876, 236)
Affinity DataIC50: 8.70E+3nMAssay Description:Antagonist activity at PDE5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM208769(US9266876, 236)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsome using dextromethorphan as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM208769(US9266876, 236)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsome using diclofenac as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM208769(US9266876, 236)
Affinity DataIC50: 7.90E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsome using testosterone as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM208769(US9266876, 236)
Affinity DataIC50: 1.00E+5nMAssay Description:Time dependent inhibition of CYP2D6 in human liver microsome using dextromethorphan as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM208769(US9266876, 236)
Affinity DataIC50: 1.00E+5nMAssay Description:Time dependent inhibition of CYP2C9 in human liver microsome using diclofenac as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM208769(US9266876, 236)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of hERG by Qpatch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed