BDBM208524 US9266870, 40::US9266870, 49

SMILES CC1COC(Cn2cc(cn2)-c2ccc(F)cn2)N(C1)C(=O)c1cc(C)ccc1-n1nccn1

InChI Key InChIKey=MPEBTPDHFLWMMX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 208524   

TargetOrexin/Hypocretin receptor type 1(Human)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM208524(US9266870, 49 | US9266870, 40)
Affinity DataIC50: 8.30nMpH: 7.4 T: 2°CAssay Description:The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM208524(US9266870, 49 | US9266870, 40)
Affinity DataIC50: 0.800nMpH: 7.4 T: 2°CAssay Description:The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM208524(US9266870, 49 | US9266870, 40)
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM208524(US9266870, 49 | US9266870, 40)
Affinity DataIC50: 7.70nMpH: 7.4 T: 2°CAssay Description:The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
Go to US Patent