BDBM207990 (2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)thiazol-4-yl)indolin-1-yl)methanone (Compound 2)

SMILES CNc1nc(cs1)-c1ccc2N(CCc2c1)C(=O)c1ccccc1OCc1ccc(Cl)cc1

InChI Key InChIKey=GOAZOFMNXDONAU-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 207990   

TargetSerine/threonine-protein kinase WNK1 [1-491](Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50: 180nMpH: 7.5Assay Description:A mixture of fluorescein labeled OSR1 peptide substrate (Toray Research Center, Inc.) and ATP was prepared with final concentrations of 10 and 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase WNK1 [1-491](Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50: 150nMpH: 7.5Assay Description:A mixture of fluorescein labeled OSR1 peptide substrate (Toray Research Center, Inc.) and ATP was prepared with final concentrations of 10 and 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase WNK1 [198-401](Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50: 1.60E+4nMAssay Description:For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase WNK1 [198-401](Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50: 8.00E+4nMAssay Description:For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase WNK1 [1-491](Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50: 64nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase WNK2 [166-489](Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50: 50nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase WNK3 [1-434](Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50: 377nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase WNK4 [1-444](Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50: 187nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase WNK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50: 420nMAssay Description:Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase WNK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human WNK1 (198 to 401 residues) using biotinylated STK3 as substrate incubated for 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSolute carrier family 12 member 2(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50: 240nMAssay Description:Inhibition of NKCC1 in human HT-29 cells assessed as inhibition of rubidium uptake incubated for 20 min by atomic absorption spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed