BDBM207565 US10501467, Example 10::US9260440, 10::US9617273, Example 10

SMILES Fc1cc2[nH]c3CC(Cc4n[nH]c(=O)c(c1)c2c34)c1ccccc1

InChI Key InChIKey=IZSILESJFBWTKL-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 207565   

TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandPNGBDBM207565(US9260440, 10 | US9617273, Example 10 | US10501467...)
Affinity DataIC50: 5.80nMpH: 8.0Assay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandPNGBDBM207565(US9260440, 10 | US9617273, Example 10 | US10501467...)
Affinity DataIC50: 5.80E+3nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandPNGBDBM207565(US9260440, 10 | US9617273, Example 10 | US10501467...)
Affinity DataIC50: 5.80E+3nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandPNGBDBM207565(US9260440, 10 | US9617273, Example 10 | US10501467...)
Affinity DataEC50:  12nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207565(US9260440, 10 | US9617273, Example 10 | US10501467...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandPNGBDBM207565(US9260440, 10 | US9617273, Example 10 | US10501467...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells pre-incubated for 30 mins before add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed