BDBM207560 US9260440, 5::US9617273, Example 5

SMILES O=c1[nH]nc2CC(Cc3[nH]c4cccc1c4c23)c1ccccc1

InChI Key InChIKey=JFJGQBKALIOSDA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 207560   

TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandPNGBDBM207560(US9260440, 5 | US9617273, Example 5)
Affinity DataIC50: 6.30nMpH: 8.0Assay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/9/2017
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Beigene

US Patent
LigandPNGBDBM207560(US9260440, 5 | US9617273, Example 5)
Affinity DataIC50: 1.60nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/9/2017
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Beigene

US Patent
LigandPNGBDBM207560(US9260440, 5 | US9617273, Example 5)
Affinity DataIC50: 164nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/9/2017
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandPNGBDBM207560(US9260440, 5 | US9617273, Example 5)
Affinity DataIC50: 6.30E+3nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Beigene

US Patent
LigandPNGBDBM207560(US9260440, 5 | US9617273, Example 5)
Affinity DataIC50: 1.60E+3nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Beigene

US Patent
LigandPNGBDBM207560(US9260440, 5 | US9617273, Example 5)
Affinity DataIC50: 1.64E+5nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent