BDBM20731 4-bromo-6-(6-hydroxy-1,2-benzoxazol-3-yl)benzene-1,3-diol::Benzisoxazole, 6::CHEMBL361078

SMILES Oc1ccc2c(noc2c1)-c1cc(Br)c(O)cc1O

InChI Key InChIKey=LZACPHWPRDKUPK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 20731   

TargetHeat shock protein HSP 90-alpha(Human)
Wyeth Research

LigandPNGBDBM20731(4-bromo-6-(6-hydroxy-1,2-benzoxazol-3-yl)benzene-1...)
Affinity DataIC50: 190nMpH: 7.3 T: 2°CAssay Description:Compounds were assayed over a threefold dilution series in a 96-well plate format to determine IC50 values. The reaction was allowed to proceed with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM20731(4-bromo-6-(6-hydroxy-1,2-benzoxazol-3-yl)benzene-1...)
Affinity DataIC50: 1.80nMAssay Description:Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM20731(4-bromo-6-(6-hydroxy-1,2-benzoxazol-3-yl)benzene-1...)
Affinity DataIC50: 30nMAssay Description:Inhibitory concentration against human ER alpha expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM20731(4-bromo-6-(6-hydroxy-1,2-benzoxazol-3-yl)benzene-1...)
Affinity DataIC50: 1.80nMAssay Description:Binding affinity to ERbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed