BDBM20694 pyrazole-based inhibitor, 37::sodium (3R,5R)-7-(3-{[(3-cyanophenyl)methyl]carbamoyl}-1-(4-fluorophenyl)-4-(propan-2-yl)-1H-pyrazol-5-yl)-3,5-dihydroxyheptanoate

SMILES CC(C)c1c(CC[C@@H](O)C[C@@H](O)CC([O-])=O)n(nc1C(=O)NCc1cccc(c1)C#N)-c1ccc(F)cc1

InChI Key InChIKey=YJOXUBMEMQKAPY-UHFFFAOYSA-M

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 20694   

LigandPNGBDBM20694(sodium (3R,5R)-7-(3-{[(3-cyanophenyl)methyl]carbam...)
Affinity DataIC50: 2.20nM EC50:  1.40nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
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Date in BDB:
3/16/2008
Entry Details Article
PubMed