BDBM20693 pyrazole-based inhibitor, 36::sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-({[3-(methoxymethyl)phenyl]methyl}carbamoyl)-4-(propan-2-yl)-1H-pyrazol-5-yl]-3,5-dihydroxyheptanoate

SMILES COCc1cccc(CNC(=O)c2nn(c(CC[C@@H](O)C[C@@H](O)CC([O-])=O)c2C(C)C)-c2ccc(F)cc2)c1

InChI Key InChIKey=WQAAILYANIAJRP-UHFFFAOYSA-M

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 20693   

LigandPNGBDBM20693(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-({[3-(metho...)
Affinity DataIC50: 7nM EC50:  0.700nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
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Date in BDB:
3/16/2008
Entry Details Article
PubMed