BDBM206760 US9260446, (I-S)::US9695185, I-S

SMILES FC(F)(F)c1ccc(CN2C(=O)[C@@]3(COc4cc5OCOc5cc34)c3ccccc23)o1

InChI Key InChIKey=NEBUOXBYNAHKFV-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 206760   

TargetSodium channel protein type 9 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM206760(US9695185, I-S | US9260446, (I-S))
Affinity DataIC50: 3nMAssay Description:The assay is based on the guanidine influx assay described by Reddy, N. L., et al., J. Med. Chem. (1998), 41(17):3298-302. The guanidine influx assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM206760(US9695185, I-S | US9260446, (I-S))
Affinity DataIC50: 3nMAssay Description:A radiotracer flux assay used to determine ion flux activity of voltage-gated sodium channels in a high-throughput microplate-based format. The assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM206760(US9695185, I-S | US9260446, (I-S))
Affinity DataIC50: 84nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM206760(US9695185, I-S | US9260446, (I-S))
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 7 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM206760(US9695185, I-S | US9260446, (I-S))
Affinity DataIC50: 54nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM206760(US9695185, I-S | US9260446, (I-S))
Affinity DataIC50: 600nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM206760(US9695185, I-S | US9260446, (I-S))
Affinity DataIC50: 170nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM206760(US9695185, I-S | US9260446, (I-S))
Affinity DataIC50: 84nMAssay Description:Inhibition of human Nav1.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM206760(US9695185, I-S | US9260446, (I-S))
Affinity DataIC50: 54nMAssay Description:Inhibition of human Nav1.7More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM206760(US9695185, I-S | US9260446, (I-S))
Affinity DataIC50: 601nMAssay Description:Inhibition of Nav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM206760(US9695185, I-S | US9260446, (I-S))
Affinity DataIC50: 173nMAssay Description:Inhibition of Nav1.6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed