BDBM206614 US9260425, 372

SMILES CCn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCN(C)CC1

InChI Key InChIKey=WKPYUMZOLALQOY-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 206614   

TargetSerine/threonine-protein kinase pim-3(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM206614(US9260425, 372)
Affinity DataKi:  0.100nMAssay Description:Inhibition of PIM3 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins in presence of ATP by caliper microfluidic mobility shift as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Genetech

US Patent
LigandPNGBDBM206614(US9260425, 372)
Affinity DataKi:  0.268nMpH: 7.2Assay Description:PIM-1, PIM-2, and PIM-3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Genetech

US Patent
LigandPNGBDBM206614(US9260425, 372)
Affinity DataKi:  0.300nMAssay Description:Inhibition of PIM1 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins in presence of ATP by caliper microfluidic mobility shift as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM206614(US9260425, 372)
Affinity DataKi:  3nMAssay Description:Inhibition of PIM2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins in presence of ATP by caliper microfluidic mobility shift as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2020
Entry Details Article
PubMed