BDBM20593 2-(4-fluorophenyl)-1-methyl-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1,2,3,4-tetrahydroisoquinolin-6-ol::tetrahydroisoquinoline derivative, 20c

SMILES CC1(N(CCc2cc(O)ccc12)c1ccc(F)cc1)c1ccc(OCCN2CCCCC2)cc1

InChI Key InChIKey=KRKKFOHLNPZSHV-UHFFFAOYSA-N

Data  7 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 20593   

TargetEstrogen receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20593(2-(4-fluorophenyl)-1-methyl-1-{4-[2-(piperidin-1-y...)
Affinity DataIC50: 38nM EC50:  1.90nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20593(2-(4-fluorophenyl)-1-methyl-1-{4-[2-(piperidin-1-y...)
Affinity DataIC50: 317nM EC50:  92nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20593(2-(4-fluorophenyl)-1-methyl-1-{4-[2-(piperidin-1-y...)
Affinity DataIC50: 92.0nMAssay Description:Inhibition of transcriptional activation by human estrogen receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20593(2-(4-fluorophenyl)-1-methyl-1-{4-[2-(piperidin-1-y...)
Affinity DataIC50: 38.0nMAssay Description:Inhibition of binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20593(2-(4-fluorophenyl)-1-methyl-1-{4-[2-(piperidin-1-y...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of transcriptional activation by human estrogen receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20593(2-(4-fluorophenyl)-1-methyl-1-{4-[2-(piperidin-1-y...)
Affinity DataIC50: 317nMAssay Description:Inhibition of binding to human estrogen receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20593(2-(4-fluorophenyl)-1-methyl-1-{4-[2-(piperidin-1-y...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at ERalpha in human MCF7 cells assessed as inhibition of estrogen-induced transcription preincubated overnight followed by estrog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2019
Entry Details Article
PubMed