BDBM20591 1-methyl-2-(4-methylphenyl)-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1,2,3,4-tetrahydroisoquinolin-6-ol::tetrahydroisoquinoline derivative, 20b

SMILES Cc1ccc(cc1)N1CCc2cc(O)ccc2C1(C)c1ccc(OCCN2CCCCC2)cc1

InChI Key InChIKey=OEUOOFPMSZOWIR-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 20591   

TargetEstrogen receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20591(1-methyl-2-(4-methylphenyl)-1-{4-[2-(piperidin-1-y...)
Affinity DataIC50: 28nM EC50:  2.90nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20591(1-methyl-2-(4-methylphenyl)-1-{4-[2-(piperidin-1-y...)
Affinity DataIC50: 421nM EC50:  486nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20591(1-methyl-2-(4-methylphenyl)-1-{4-[2-(piperidin-1-y...)
Affinity DataIC50: 28.0nMAssay Description:Inhibition of binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20591(1-methyl-2-(4-methylphenyl)-1-{4-[2-(piperidin-1-y...)
Affinity DataIC50: 486nMAssay Description:Inhibition of transcriptional activation by human estrogen receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20591(1-methyl-2-(4-methylphenyl)-1-{4-[2-(piperidin-1-y...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of transcriptional activation by human estrogen receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20591(1-methyl-2-(4-methylphenyl)-1-{4-[2-(piperidin-1-y...)
Affinity DataIC50: 421nMAssay Description:Inhibition of binding to human estrogen receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed