BDBM20589 1-{4-[2-(azepan-1-yl)ethoxy]phenyl}-1-methyl-2-phenyl-1,2,3,4-tetrahydroisoquinolin-6-ol::tetrahydroisoquinoline derivative, 26a

SMILES CC1(N(CCc2cc(O)ccc12)c1ccccc1)c1ccc(OCCN2CCCCCC2)cc1

InChI Key InChIKey=JIJPAWIWJLCFNW-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 20589   

TargetEstrogen receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20589(1-{4-[2-(azepan-1-yl)ethoxy]phenyl}-1-methyl-2-phe...)
Affinity DataIC50: 56nM EC50:  1.5nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20589(1-{4-[2-(azepan-1-yl)ethoxy]phenyl}-1-methyl-2-phe...)
Affinity DataIC50: 200nM EC50:  80nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20589(1-{4-[2-(azepan-1-yl)ethoxy]phenyl}-1-methyl-2-phe...)
Affinity DataIC50: 200nMAssay Description:Inhibition of binding to human estrogen receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20589(1-{4-[2-(azepan-1-yl)ethoxy]phenyl}-1-methyl-2-phe...)
Affinity DataIC50: 80.0nMAssay Description:Inhibition of transcriptional activation by human estrogen receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20589(1-{4-[2-(azepan-1-yl)ethoxy]phenyl}-1-methyl-2-phe...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of transcriptional activation by human estrogen receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20589(1-{4-[2-(azepan-1-yl)ethoxy]phenyl}-1-methyl-2-phe...)
Affinity DataIC50: 56.0nMAssay Description:Inhibition of binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed