BDBM205480 PDD00017238 (5)::US10508086, Example 90::US10995073, Example 90

SMILES Cc1nc(C)c(Cn2c3ccc(cc3n(-c3ncns3)c2=O)S(=O)(=O)NC2(C)CC2)s1

InChI Key InChIKey=FLUZEVGWXJVSPX-UHFFFAOYSA-N

Data  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 205480   

TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

LigandPNGBDBM205480(PDD00017238 (5) | US10508086, Example 90 | US10995...)
Affinity DataIC50: 40nMpH: 7.4Assay Description:Briefly, PARG in vitro assays were conducted in a total volume of 15 μL in a standard 384-well format. A total of 5 μL of human full length...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

LigandPNGBDBM205480(PDD00017238 (5) | US10508086, Example 90 | US10995...)
Affinity DataEC50:  40nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetADP-ribosylhydrolase ARH3(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM205480(PDD00017238 (5) | US10508086, Example 90 | US10995...)
Affinity DataIC50: 1.00E+5nMAssay Description:ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM205480(PDD00017238 (5) | US10508086, Example 90 | US10995...)
Affinity DataIC50: 1.50E+5nMAssay Description:PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

LigandPNGBDBM205480(PDD00017238 (5) | US10508086, Example 90 | US10995...)
Affinity DataEC50:  40nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent

TargetADP-ribosylhydrolase ARH3(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM205480(PDD00017238 (5) | US10508086, Example 90 | US10995...)
Affinity DataIC50: 1.00E+5nMAssay Description:ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM205480(PDD00017238 (5) | US10508086, Example 90 | US10995...)
Affinity DataIC50: 1.50E+5nMAssay Description:PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent