BDBM205479 PDD00017273 (4)::US20230278998, Compound PDD00017273::US20250042891, Compound PDD00017273

SMILES Cc1cc(n(n1)C)CN2c3ccc(cc3C(=O)N(C2=O)Cc4cnc(s4)C)S(=O)(=O)NC5(CC5)C

InChI Key InChIKey=IFWUBRBMMNTBRZ-UHFFFAOYSA-N

Data  3 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 205479   

TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

LigandPNGBDBM205479(PDD00017273 (4) | US20230278998, Compound PDD00017...)
Affinity DataIC50: 26nMpH: 7.4Assay Description:Briefly, PARG in vitro assays were conducted in a total volume of 15 μL in a standard 384-well format. A total of 5 μL of human full length...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

LigandPNGBDBM205479(PDD00017273 (4) | US20230278998, Compound PDD00017...)
Affinity DataEC50:  26nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

LigandPNGBDBM205479(PDD00017273 (4) | US20230278998, Compound PDD00017...)
Affinity DataEC50:  37nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

LigandPNGBDBM205479(PDD00017273 (4) | US20230278998, Compound PDD00017...)
Affinity DataIC50: 100nMAssay Description:PARG in vitro assays were conducted in standard 384-well plates in a total volume of 15 μL. 5 μL of PARG (389-976) (manufactured by Chempar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetPoly(ADP-ribose) glycohydrolase [389-976](Human)
Shanghai Yingli Pharmaceutical Co.

US Patent
LigandPNGBDBM205479(PDD00017273 (4) | US20230278998, Compound PDD00017...)
Affinity DataIC50: 5.5nMAssay Description:PARG in vitro assays were conducted in standard 384-well plates in a total volume of 15 μL. 5 μL of PARG (389-976) (manufactured by Chempartner Chemi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2025
Entry Details
Go to US Patent

TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

LigandPNGBDBM205479(PDD00017273 (4) | US20230278998, Compound PDD00017...)
Affinity DataEC50:  26nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed