BDBM205303 US9249125, 56

SMILES Cc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4cccc(OCCN5CCOCC5)c4)C(C)(C)C)c4ccccc34)n2)cc2cn[nH]c12

InChI Key InChIKey=QJIXTISVQSBZTF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 205303   

TargetMitogen-activated protein kinase 14(Human)
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US Patent
LigandPNGBDBM205303(US9249125, 56)
Affinity DataIC50: 46nMAssay Description:The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the lev...More data for this Ligand-Target Pair
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Date in BDB:
12/12/2016
Entry Details
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM205303(US9249125, 56)
Affinity DataIC50: 2nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
12/12/2016
Entry Details
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TargetTyrosine-protein kinase SYK(Human)
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US Patent
LigandPNGBDBM205303(US9249125, 56)
Affinity DataIC50: 3nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM205303(US9249125, 56)
Affinity DataIC50: 1.33E+4nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details
Go to US Patent