BDBM205094 US9556147, 3

SMILES CC(C)(C)c1cc2c(c(c1)F)C(=O)N(N=C2)c3cccc4c3C[C@@H](CC5=C4C=C(C(=O)N5C)Nc6ccc(cn6)C(=O)N7CCOCC7)O

InChI Key InChIKey=ACFBKRAWAGNCMP-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 205094   

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM205094(US9556147, 3)
Affinity DataIC50: 0.910nMpH: 7.2Assay Description:The assay is a capture of radioactive 33P phosphorylated product through filtration. The interactions of BTK, biotinylated SH2 peptide substrate (Src...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM205094(US9556147, 3)
Affinity DataIC50: 26nMAssay Description:Inhibition of BTK in goat F(ab')2 anti-human IgM-stimulated human whole blood assessed as suppression of CD69 expression on B cells pretreated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM205094(US9556147, 3)
Affinity DataIC50: 1nMAssay Description:Inhibition of Kinase Tracer 178 binding to biotinylated-BTK (unknown origin) measured after 18 to 24 hrs by Europium-labeled Streptavidin conjugate b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM205094(US9556147, 3)
Affinity DataIC50: 24nMAssay Description:Inhibition of BTK in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)