BDBM205085 US9556145, example 5::methyl 3-chloro-2-(((3R,6R)-6-methylpiperidin-3-yl)oxy)isonicotinate

SMILES COC(=O)c1ccnc(O[C@@H]2CC[C@@H](C)N(C2)C(=O)c2ccccc2-n2nccn2)c1Cl

InChI Key InChIKey=PMVGXKCLTREHLI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 205085   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205085(US9556145, example 5 | methyl 3-chloro-2-(((3R,6R)...)
Affinity DataIC50: 11nMAssay Description:TBDIn a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205085(US9556145, example 5 | methyl 3-chloro-2-(((3R,6R)...)
Affinity DataIC50: 953nMAssay Description:TBDIn a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details
Go to US Patent