BDBM205084 US9556145, example 4::methyl 5-bromo-2- {[(3r,6r)-6-methyl-1- {[2-(2h-1,2,3-triazol- 2-yl)phenyl]carbon- yl}piperidin-3- yl]oxy}pyridine-4- carboxylate

SMILES COC(=O)c1cc(O[C@@H]2CC[C@@H](C)N(Cc3ccccc3-n3nccn3)C2)ncc1Br

InChI Key InChIKey=VVSGOAQUVKVPIV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 205084   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205084(US9556145, example 4 | methyl 5-bromo-2- {[(3r,6r)...)
Affinity DataIC50: 60nMAssay Description:TBDIn a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205084(US9556145, example 4 | methyl 5-bromo-2- {[(3r,6r)...)
Affinity DataIC50: 28.9nMAssay Description:TBDIn a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details
Go to US Patent