BDBM205083 US9556145, example 3::methyl 2-{[(3r,6r)-6- methyl-1-{[2-(2h-1,2,3- triazol-2-yl)phenyl]- carbonyl}piperidin-3- yl]oxy}-5-(trifluoro- methyl)pyridine-4- carboxylate

SMILES COC(=O)c1cc(O[C@@H]2CC[C@@H](C)N(C2)C(=O)c2ccccc2-n2nccn2)ncc1C(F)(F)F

InChI Key InChIKey=HCOYXYNEARNHMC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 205083   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205083(US9556145, example 3 | methyl 2-{[(3r,6r)-6- methy...)
Affinity DataIC50: 57nMAssay Description:TBDIn a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205083(US9556145, example 3 | methyl 2-{[(3r,6r)-6- methy...)
Affinity DataIC50: 28nMAssay Description:TBDIn a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details
Go to US Patent