BDBM20417 3-isoquinolin-5-yl-1-{2-[4-(trifluoromethyl)phenyl]ethyl}urea::CHEMBL103063::isoquinoline deriv., 14d

SMILES FC(F)(F)c1ccc(CCNC(=O)Nc2cccc3cnccc23)cc1

InChI Key InChIKey=GVBJQELVGBOZCZ-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 20417   

LigandPNGBDBM20417(CHEMBL103063 | 3-isoquinolin-5-yl-1-{2-[4-(trifluo...)
Affinity DataEC50:  19nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20417(CHEMBL103063 | 3-isoquinolin-5-yl-1-{2-[4-(trifluo...)
Affinity DataIC50: 19nMAssay Description:Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM20417(CHEMBL103063 | 3-isoquinolin-5-yl-1-{2-[4-(trifluo...)
Affinity DataKi:  22nMAssay Description:Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed