BDBM20416 3-isoquinolin-5-yl-1-{[3-(trifluoromethyl)phenyl]methyl}urea::CHEMBL322396::isoquinoline deriv., 14c

SMILES FC(F)(F)c1cccc(CNC(=O)Nc2cccc3cnccc23)c1

InChI Key InChIKey=KPELIYBHXGTRBI-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 20416   

LigandPNGBDBM20416(3-isoquinolin-5-yl-1-{[3-(trifluoromethyl)phenyl]m...)
Affinity DataEC50:  51nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20416(3-isoquinolin-5-yl-1-{[3-(trifluoromethyl)phenyl]m...)
Affinity DataIC50: 11nMAssay Description:Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM20416(3-isoquinolin-5-yl-1-{[3-(trifluoromethyl)phenyl]m...)
Affinity DataKi:  23nMAssay Description:Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed