BDBM203908 US9539260, C24::US9539260, C25::US9763952, Example C25

SMILES COc1ncc(cc1C#N)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3COCCO3)cc12

InChI Key InChIKey=PCSSMVIQOOZSCF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 203908   

LigandPNGBDBM203908(US9539260, C25 | US9539260, C24 | US9763952, Examp...)
Affinity DataIC50: 560nMT: 2°CAssay Description:Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2018
Entry Details
Go to US Patent

LigandPNGBDBM203908(US9539260, C25 | US9539260, C24 | US9763952, Examp...)
Affinity DataIC50: 3nMT: 2°CAssay Description:Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2018
Entry Details
Go to US Patent

LigandPNGBDBM203908(US9539260, C25 | US9539260, C24 | US9763952, Examp...)
Affinity DataIC50: 474nMT: 2°CAssay Description:Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2018
Entry Details
Go to US Patent

LigandPNGBDBM203908(US9539260, C25 | US9539260, C24 | US9763952, Examp...)
Affinity DataIC50: 12.5nMT: 2°CAssay Description:Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2018
Entry Details
Go to US Patent

LigandPNGBDBM203908(US9539260, C25 | US9539260, C24 | US9763952, Examp...)
Affinity DataIC50: 560nMAssay Description:The kinase reaction is performed in a final volume of 50 μl per well of a half area COSTAR, 96 well plate. The final concentrations of ATP and p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2019
Entry Details
Go to US Patent

LigandPNGBDBM203908(US9539260, C25 | US9539260, C24 | US9763952, Examp...)
In Depth
Date in BDB:
7/26/2019
Entry Details
Go to US Patent

LigandPNGBDBM203908(US9539260, C25 | US9539260, C24 | US9763952, Examp...)
Affinity DataIC50: 474nMAssay Description:The kinase reaction is performed in a final volume of 50 μl per well of a half area COSTAR, 96 well plate. The final concentrations of ATP and p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2019
Entry Details
Go to US Patent

LigandPNGBDBM203908(US9539260, C25 | US9539260, C24 | US9763952, Examp...)
Affinity DataIC50: 12.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2019
Entry Details
Go to US Patent