BDBM203567 US9221809, 124

SMILES C[C@@H]1CC[C@H](CN1)Nc1nc([nH]c(=O)c1-c1nc2ccccc2s1)N1CCOCC1

InChI Key InChIKey=RPLNTIISFSQCAJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 203567   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM203567(US9221809, 124)
Affinity DataIC50: 114nMpH: 7.2 T: 2°CAssay Description:A 20 ul reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (RP7030, Molecular...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2016
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM203567(US9221809, 124)
Affinity DataIC50: 580nMAssay Description:Inhibition of IRAK4-mediated NFkappaB activation in human THP1-XBlue cells assessed as LPS-induced secreted embryonic alkaline phosphatase activity t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM203567(US9221809, 124)
Affinity DataIC50: 93nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed