BDBM203371 US9539260, B30::US9539260, D1::US9763952, Example D1

SMILES COc1ncc(cc1C#N)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)c3cn(C)cn3)cc12

InChI Key InChIKey=BWLCKZUCOMEQEQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 203371   

LigandPNGBDBM203371(US9539260, D1 | US9539260, B30 | US9763952, Exampl...)
In Depth
Date in BDB:
7/26/2019
Entry Details
US Patent

LigandPNGBDBM203371(US9539260, D1 | US9539260, B30 | US9763952, Exampl...)
Affinity DataIC50: 5nMT: 2°CAssay Description:Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2018
Entry Details
US Patent

LigandPNGBDBM203371(US9539260, D1 | US9539260, B30 | US9763952, Exampl...)
Affinity DataIC50: 15.5nMT: 2°CAssay Description:Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2018
Entry Details
US Patent

LigandPNGBDBM203371(US9539260, D1 | US9539260, B30 | US9763952, Exampl...)
Affinity DataIC50: 15.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2019
Entry Details
US Patent

LigandPNGBDBM203371(US9539260, D1 | US9539260, B30 | US9763952, Exampl...)
Affinity DataIC50: 216nMT: 2°CAssay Description:Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2018
Entry Details
US Patent

LigandPNGBDBM203371(US9539260, D1 | US9539260, B30 | US9763952, Exampl...)
Affinity DataIC50: 216nMAssay Description:The kinase reaction is performed in a final volume of 50 μl per well of a half area COSTAR, 96 well plate. The final concentrations of ATP and p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2019
Entry Details
US Patent

LigandPNGBDBM203371(US9539260, D1 | US9539260, B30 | US9763952, Exampl...)
Affinity DataIC50: 424nMAssay Description:The kinase reaction is performed in a final volume of 50 μl per well of a half area COSTAR, 96 well plate. The final concentrations of ATP and p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2019
Entry Details
US Patent

LigandPNGBDBM203371(US9539260, D1 | US9539260, B30 | US9763952, Exampl...)
Affinity DataIC50: 424nMT: 2°CAssay Description:Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2018
Entry Details
US Patent