BDBM202199 US9233983, P-14

SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(N2CCOc3cc(cc(F)c3C2=O)C2CC2)c1CO

InChI Key InChIKey=LNWKIIHCZNTSSD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 202199   

TargetTyrosine-protein kinase BTK(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM202199(US9233983, P-14)
Affinity DataIC50: 1nMAssay Description:The inhibition assays were performed using the generic tyrosine kinase assay kit from C is Bio (HTRF KinEASE-TK #62TK0PEB). The assay is based on the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM202199(US9233983, P-14)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human full length BTK preincubated for 10 mins followed by Tk-biotin peptide substrate addition after 90 mins by TR-FRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Mouse)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM202199(US9233983, P-14)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of C57BL/6J mouse BTK assessed as decrease in anti-mouse IgM antibody stimulated BCR mediated CD69 upregulation preincubated for 30 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed