BDBM202131 US9233983, I-2

SMILES CN1CCN(Cc2ccc(nc2)-c2cc3c(ccnc3[nH]2)-c2cccc(N3CCOc4cc(cc(F)c4C3=O)C3CC3)c2CO)CC1

InChI Key InChIKey=CZRBWWRXBQATBP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 202131   

TargetTyrosine-protein kinase BTK(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM202131(US9233983, I-2)
Affinity DataIC50: 1nMAssay Description:The inhibition assays were performed using the generic tyrosine kinase assay kit from C is Bio (HTRF KinEASE-TK #62TK0PEB). The assay is based on the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM202131(US9233983, I-2)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human full length BTK preincubated for 10 mins followed by Tk-biotin peptide substrate addition after 90 mins by TR-FRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Mouse)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM202131(US9233983, I-2)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of C57BL/6J mouse BTK assessed as decrease in anti-mouse IgM antibody stimulated BCR mediated CD69 upregulation preincubated for 30 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed