BDBM201301 US9187424, 65::US9187424, 77

SMILES COc1ccc(cc1)C1=C(C#N)C(=O)NC(C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F

InChI Key InChIKey=QEMIMKHKUITFJX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 201301   

LigandPNGBDBM201301(US9187424, 77 | US9187424, 65)
Affinity DataIC50: 3nMpH: 7.4Assay Description:The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details
Go to US Patent

LigandPNGBDBM201301(US9187424, 77 | US9187424, 65)
Affinity DataIC50: 27nMpH: 7.4Assay Description:The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details
Go to US Patent

LigandPNGBDBM201301(US9187424, 77 | US9187424, 65)
Affinity DataIC50: 96nMpH: 7.4 T: 2°CAssay Description:MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details
Go to US Patent

LigandPNGBDBM201301(US9187424, 77 | US9187424, 65)
Affinity DataIC50: 89nMpH: 7.4 T: 2°CAssay Description:MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details
Go to US Patent

LigandPNGBDBM201301(US9187424, 77 | US9187424, 65)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human recombinant MGAT2 expressed in Sf9 cell membrane using 2-monooleglycerol and [H3]-oleoyl-CoA as substrates incubated for 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
LigandPNGBDBM201301(US9187424, 77 | US9187424, 65)
Affinity DataIC50: 20nMAssay Description:Inhibition of mouse recombinant MGAT2 expressed in Sf9 cell membrane using 2-oleoylglycerol and oleoyl-CoA as substrates incubated for 10 mins by LCM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed