BDBM201232 US9187424, 2::US9187424, 2-1

SMILES Cc1ccc(cc1)C1=C(c2nnn[nH]2)C(=O)NC(C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F

InChI Key InChIKey=AEMPUAWUDAMJBV-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 201232   

LigandPNGBDBM201232(US9187424, 2-1 | US9187424, 2)
Affinity DataIC50: 5nMpH: 7.4Assay Description:The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details
Go to US Patent

LigandPNGBDBM201232(US9187424, 2-1 | US9187424, 2)
Affinity DataIC50: 8nMpH: 7.4Assay Description:The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details
Go to US Patent

LigandPNGBDBM201232(US9187424, 2-1 | US9187424, 2)
Affinity DataIC50: 85nMpH: 7.4 T: 2°CAssay Description:MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details
Go to US Patent

LigandPNGBDBM201232(US9187424, 2-1 | US9187424, 2)
Affinity DataIC50: 35nMpH: 7.4 T: 2°CAssay Description:MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details
Go to US Patent

LigandPNGBDBM201232(US9187424, 2-1 | US9187424, 2)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of human MGAT2 using 2-oleoylglycerol and oleoyl-coenzyme A as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM201232(US9187424, 2-1 | US9187424, 2)
Affinity DataIC50: 18nMAssay Description:Inhibition of mouse MGAT2 using 2-oleoylglycerol and oleoyl-coenzyme A as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM201232(US9187424, 2-1 | US9187424, 2)
Affinity DataEC50: >5.00E+4nMAssay Description:Transactivation of PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as increase in luciferase activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed