BDBM20120 (2S)-N-(cyanomethyl)-3-phenyl-2-[(4-phenylphenyl)formamido]propanamide::phenylalanine derivative, 44

SMILES O=C(NCC#N)[C@H](Cc1ccccc1)NC(=O)c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=DWFFMEGYLGKXHE-UHFFFAOYSA-N

Data  5 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 20120   

TargetPapain(Papaya)
Radboud University Nijmegen

Curated by ChEMBL
LigandPNGBDBM20120((2S)-N-(cyanomethyl)-3-phenyl-2-[(4-phenylphenyl)f...)
Affinity DataIC50: 220nMAssay Description:Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetPapain(Papaya)
Radboud University Nijmegen

Curated by ChEMBL
LigandPNGBDBM20120((2S)-N-(cyanomethyl)-3-phenyl-2-[(4-phenylphenyl)f...)
Affinity DataKi:  16nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20120((2S)-N-(cyanomethyl)-3-phenyl-2-[(4-phenylphenyl)f...)
Affinity DataKi:  240nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20120((2S)-N-(cyanomethyl)-3-phenyl-2-[(4-phenylphenyl)f...)
Affinity DataKi:  300nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetProcathepsin L(Bovine)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20120((2S)-N-(cyanomethyl)-3-phenyl-2-[(4-phenylphenyl)f...)
Affinity DataKi:  550nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetCathepsin B(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM20120((2S)-N-(cyanomethyl)-3-phenyl-2-[(4-phenylphenyl)f...)
Affinity DataKi:  3.92E+3nMpH: 6.0Assay Description:Inhibition of human liver cathepsin B using Cbz-Arg-Arg-pNA as substrate at pH 6 incubated for 30 mins measured for 20 mins by photometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMed